Salicylate reduces cisplatin nephrotoxicity by inhibition of tumor necrosis factor-α
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Therapeutic effect of psoralen on muscle atrophy induced by tumor necrosis factor-α
Objective(s): To observe and determine the effect and mechanism of psoralen on tumor necrosis factor-α (TNF-α)-induced muscle atrophy.Materials and Methods: Three sets of C2C12 cells, including blank control, TNF-α (10 or 20 ng/ml) treatment and a TNF-α (10 or 20 ng/ml) plus psoralen (80 μM) administration were investigated. Cell viabili...
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Tumor necrosis factor α (TNF-α) plays a central role in the pathophysiology of Alzheimer's disease (AD). Food and Drug Administration-approved biologic TNF-α inhibitors are thus a potential treatment for AD, but they do not cross the blood-brain barrier. In this short review, we discuss the involvement of TNF-α in AD, challenges associated with the development of existing biologic TNF-α inhibit...
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1 CYSTIC FIBROSIS AIRWAY EPITHELIAL CELLS. 2 3 Running title: Azithromycin reduces TNF-α in cystic fibrosis cells. 4 Cristina Cigana, Baroukh Maurice Assael and Paola Melotti* 5 Cystic Fibrosis Center, Azienda Ospedaliera di Verona, Verona, ITALY. 6 7 *Corresponding author. Mailing address: Cystic Fibrosis Center Azienda Ospedaliera di 8 Verona, piazzale Stefani, 1 37126 Verona, Italy. Phone: +...
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Cisplatin has been used for the treatment of various solid cancers or sarcomas; however, it can induce severe adverse effects. Among these adverse effects, nephrotoxicity, which has the potential to be a dose-limiting factor of this agent, develops due to the secretion of tumor necrosis factor-α (TNF-α) from macrophages; however, the precise mechanisms are still unclear. To elucidate possible m...
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Background: It has been suggested that inflammation might be implicated in the gestational diabetes mellitus (GDM) complications, including insulin resistance. The aims of the current study were to explore maternal circulating values of TNF-α, adiponectin and the adiponectin/TNF-α ratio in women with GDM compared with normal pregnancy and their relationships with metabolic syndrome ...
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ژورنال
عنوان ژورنال: Kidney International
سال: 2004
ISSN: 0085-2538
DOI: 10.1111/j.1523-1755.2004.00413.x